Cyclobenzaprine Oral Route Side Effects
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Side effects, also known as Adverse Drug Reactions (ADR), are claimed to be the fourth leading cause of death. It is used in conjunction with rest, physical therapy, and other treatments to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries. It belongs to a class of drugs known as skeletal muscle relaxants. It works by relaxing the muscles by acting on the brain and nervous system.
In preclinical research, cyclobenzaprine reduced skeletal muscle hyperactivity. Research indicates that it primarily acts within the central nervous system in the brain stem. Cyclobenzaprine comes as a tablet and an extended-release capsule to take by mouth. The tablet is usually taken with or without food three times a day. The extended-release capsule is usually taken with or without food once a day. Do not take this drug for more than 3 weeks without talking to your doctor.
Does Flexeril Increase or Decrease Blood Pressure?
Ell your doctor if your condition lasts after 2 to 3 weeks or if it gets worse. Since overdosage is often deliberate, patients may attempt suicide by other means during the recovery phase. Safety and effectiveness of FLEXERIL in pediatric patients below 15 years of age have not been established. FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants. Animal studies don’t always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed.
Hyperpyretic crisis seizures, and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs. Call your doctor or local poison control center immediately if you have an allergic reaction. Call 911 or go to the nearest emergency room if your symptoms are severe. Do not take this drug again if you’ve ever had an allergic reaction to it.
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Call emergency for help if you have problems breathing or unusual sleepiness. Flexeril interacts with other medications and drugs that slow the brain’s processes, such as alcohol, barbiturates, benzodiazepines, and narcotics. Common side effects of Flexeril include drowsiness, dry mouth, fatigue, headaches, and dizziness.
Cyclobenzaprine (Flexeril) Side Effects
If signs of toxicity occur at any time during this period, extended monitoring is required. Monitoring of plasma drug levels should not guide management of the patient. Dialysis is probably of no value because of low plasma concentrations of the drug. In the higher dose groups this microscopic change https://flexeril.live was seen after 26 weeks and even earlier in rats which died prior to 26 weeks; at lower doses, the change was not seen until after 26 weeks. The plasma concentration of cyclobenzaprine is increased in patients with hepatic impairment (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Hepatic Impairment).
- Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.
- The phase IV clinical study analyzes which people take Flexeril and have High blood pressure.
- For most patients, the recommended dose of Flexeril is 5 mg three times a day.
- When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below.
Cyclobenzaprine is structurally and pharmacologically related to tricyclic antidepressants. Among the most dreaded toxicities linked with cyclical antidepressants, overdoses affect fast-acting sodium channels in the cardiac conduction system. Cyclical antidepressants block the cardiac sodium channel and cause prolongation of cardiac depolarization, which manifests as QRS widening on electrocardiograms. There is also evidence that cyclical antidepressants may decrease the seizure threshold by interfering with chloride conductance on the GABA receptor. Drug interactions of Flexeril include tricyclic antidepressants because Flexeril is chemically related to this class of drugs.
What are the side effects of Flexeril?
It helps relieve pain, stiffness, and discomfort caused by strains, sprains, or injuries to your muscles. However, this medicine does not take the place of rest, exercise or physical therapy, or other treatment that your doctor may recommend for your medical problem. Cyclobenzaprine acts on the central nervous system (CNS) to produce its muscle relaxant effects.
Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. Automatically receive FDA alerts, drug interaction warnings, plus data on food, allergy & condition interactions. Sometimes, muscle relaxants like cyclobenzaprine are used “off-label” to treat conditions they’re not approved for, such as fibromyalgia. This is not a complete list of side effects and others may occur.